2006 CPEO Military List Archive

From: Lenny Siegel <lsiegel@cpeo.org>
Date: 27 Jan 2006 15:24:34 -0000
Reply: cpeo-military
Subject: [CPEO-MEF] California explains perchlorate health goal
 
Development of a Health-Protective Drinking Water Level for Perchlorate

David Ting, Robert A. Howd, Anna M. Fan, George V. Alexeeff
Office of Environmental Health Hazard Assessment
California Environmental Protection Agency
Environmental Health Perspectives-in-Press
(January, 2006)

Abstract

We evaluated animal and human toxicity data for perchlorate and identified reduction of thyroidal iodide uptake as the critical endpoint in the development of a health-protective drinking water level (also known as the Public Health Goal or PHG) for the chemical. This work was done under the drinking water program of the Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency. For dose-response characterization, we applied benchmark-dose modeling to human data provided by Greer et al. (2002) and determined a point of departure (the 95% lower confidence limit for 5% inhibition of iodide uptake) of 0.0037 mg/kg-day. A PHG of 6 ppb was calculated by using an uncertainty factor (UF) of 10, a relative source contribution (RSC) of 60 percent, and exposure assumptions specific to pregnant women. The California Department of Health Services will use the PHG, together with other considerations, such as economic impact and engineering feasibility, to develop a California Maximum Contaminant Level (MCL) for perchlorate. We consider the PHG to be adequately protective of sensitive subpopulations, including pregnant women, their fetuses, infants, and people with hypothyroidism.

To download the article, go to
http://ehp.niehs.nih.gov/docs/2006/8684/abstract.html
--
Lenny Siegel
Director, Center for Public Environmental Oversight
c/o PSC, 278-A Hope St., Mountain View, CA 94041
Voice: 650/961-8918 or 650/969-1545
Fax: 650/961-8918
http://www.cpeo.org

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