2003 CPEO Military List Archive

From: steve@miltoxproj.org
Date: 22 Sep 2003 15:12:10 -0000
Reply: cpeo-military
Subject: Re: [CPEO-MEF] NAS Perchlorate Study
It would be very helpful to have background information on the members of
the NAS perchorate study committee in addition to that posted on the NAS
site (i.e. who funds their work, etc.). Does anyone out there have such
information or want to take on that task?

Steve Taylor

----- Original Message ----- 
From: "Lenny Siegel" <lsiegel@cpeo.org>
To: "Military Environmental Forum" <cpeo-military@igc.topica.com>
Sent: Friday, September 19, 2003 12:58 PM
Subject: [CPEO-MEF] NAS Perchlorate Study

> Information on the National Research Council (National Academy of
> Sciences) perchlorate study is now available at
> To read the original, you'll probably need to cut and paste the URL, but
> I have pasted the entire task statement below.
> Biographical sketches for the members of the NRC Committee to Assess the
> Health Implications of Perchlorate Ingestion may be found at
> The Committee's first meeting will be October 27, 2003 at the Academy's
> new building at
>  500 5th Street, N.W., Washington, DC.
> The announcement says, "If you would like to attend the sessions of this
> meeting that are open to the public or need more information please
> Contact Name: Jennifer Saunders
> Email: jsaunder@nas.edu
> Phone: 202-334-2616
> Fax: 202-334-1393"
> Lenny
> ***
> Project Title: Committee to Assess the Health Implications of
> Perchlorate Ingestion
> Date Posted: <Posted: 07/14/2003>
> Project Identification Number: BEST-K-03-05-A
> Major Unit:
> Division on Earth and Life Studies
> Institute of Medicine
> Sub Unit:
> Board on Environmental Studies and Toxicology
> Board on Health Sciences Policy
> Project Scope:
> A committee of the National Academies will assess the adverse health
> effects resulting from ingestion of perchlorate from a clinical,
> toxicological, medical, and public health perspective. The committee
> will critically evaluate the scientific literature, including both human
> and animal data, and will assess the key studies underlying EPA's 2002
> Draft Toxicological Review and Risk Characterization for Perchlorate in
> terms of quality, reliability, and relevance to draw conclusions about
> the health implications of exposure to low levels of perchlorate in
> drinking water.
> In conducting its assessment, the committee will first address the
> following basic scientific issues:
> 1. The current state of the science regarding potential adverse effects
> resulting from disruption of thyroid function in humans and laboratory
> animals at various stages of life. Specifically, the committee will
> evaluate whether science supports the model that predicts potential
> adverse neurodevelopmental and neoplastic effects from changes in
> thyroid hormone regulation resulting from disruption of iodide uptake by
> the thyroid gland. The committee will indicate its level of confidence
> in the model.
> 2. The levels at which chronic inhibition of iodide uptake may lead to
> adverse (not just adaptive) health effects in humans, especially
> sensitive subpopulations. The committee will consider the influence of
> iodine in the diet on the levels at which adverse effects would be
> observed, especially in sensitive subpopulations, and will indicate its
> degree of confidence in the levels that it proposes.
> 3. The levels at which changes in thyroid hormones may lead to adverse
> (not just adaptive) health effects in humans, especially sensitive
> subpopulations. The committee will indicate its confidence in these
> The committee will evaluate the animal studies used to assess human
> health effects from ingestion of perchlorate with particular attention
> to key endpoints, including changes in brain morphometry, behavior,
> thyroid hormone levels, and thyroid histopathology. The committee will
> indicate its level of confidence in the relevance of the adverse effects
> observed in the animal studies to human health, especially sensitive
> subpopulations, and will specifically address the validity of the models
> that extrapolate changes in brain morphometry in rats to adverse effects
> in the human population, especially sensitive subpopulations. The
> committee will also indicate whether adverse effects, other than those
> associated with iodide update inhibition, may result from daily
> ingestion of low levels of perchlorate.
> Based on the above review, the committee will determine whether EPA's
> findings in its 2002 Draft Toxicological Review and Risk
> Characterization for Perchlorate are consistent with the current
> scientific evidence. Specifically, the committee will determine whether
> EPA considered all relevant literature (both supporting and
> non-supporting), consistently critiqued that literature, and then used
> appropriate scientific studies to develop its health risk assessment. If
> the committee finds deficiencies in EPA's analysis, such as lack of
> consideration of a key study, the committee will provide suggestions as
> to how EPA might modify its assessment. The committee will provide a
> range of values consistent with scientific evidence for percent iodide
> uptake that would be protective of individuals at various life stages
> and thyroid status. The committee will also provide information on the
> basis of the scientific evidence that can be used to inform the
> selection of uncertainty factors used in the approximation of a safe
> lifetime exposure for humans, especially sensitive subpopulations.
> As a final task, the committee will suggest specific scientific research
> that could reduce the uncertainty in the current understanding of human
> health effects associated with low-level perchlorate ingestion.
> Specifically, it will suggest research that could clarify safe levels of
> exposure for sensitive subpopulations. Rough estimates for timeframe,
> costs, and potential to reduce overall uncertainty will be provided for
> the specific research studies suggested.
> The project sponsor is the Environmental Project Agency. Co-sponsorship
> anticipated from Department of Defense, Department of Energy, and
> National Aeronautics and Space Administration.
> The approximate starting date for the project is 06/05/2003.
> One report will be issued in approximately 15 months. Project Duration:
> 15 months
> -- 
> Lenny Siegel
> Director, Center for Public Environmental Oversight
> c/o PSC, 278-A Hope St., Mountain View, CA 94041
> Voice: 650/961-8918 or 650/969-1545
> Fax: 650/961-8918
> <lsiegel@cpeo.org>
> http://www.cpeo.org
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